Searching for Small Molecules with Antioxidant and Anticoagulant Properties to Fight Thrombosis

Being thrombosis a complex process involving multiple pathways, drugs acting simultaneously as antioxidants and anticoagulants would be of value to prevent and treat this pathology. We have recently discovered a new class of sulfated polyphenols derivatives which exhibited both in vitro and in vivo antithrombotic activity. That these derivatives showed water solubility and no putative toxicity was observed in vivo for the investigated compounds. Herein, the antioxidant potential of these polyphenolic derivatives was investigated by the DPPH and peroxyl radical scavenging activity assays and by the copper ion-chelating ability assay. The results showed that the persulfate of chlorogenic acid (7) was the most promising derivative, displaying antioxidant activity both by the DPPH and the peroxyl radical scavenging assays. Additionally, this compound was able to chelate Cu2+ ions. The gathered information provided a model for the future design of dual anticoagulant-antioxidant agents.